1-(3-p-Tolylisoxazol-5-yl)cyclohexanol
نویسندگان
چکیده
The title compound, C(16)H(19)NO(2), contains two mol-ecules in the asymmetric unit. Each mol-ecule is composed of three inter-connected rings, two essentially planar rings, viz. the isoxazole and the methyl-benzyl aromatic ring [maximum deviations of 0.0027 (13) and 0.0031 (19) Å from the isoxazole and methylbenzyl ring planes, respectively, in the first molecule, 0.0018 (12) and 0.019 (2) Å in the second molecule], and one cyclo-hexa-nol ring having a chair conformation. Although the two mol-ecules have similar bond distances and angles, they differ in the orientation of the cyclo-hexa-nol ring with respect to the tolyl-isoxazole unit. In the first mol-ecule, the dihedral angle between the isoxazole and methyl-benzyl rings is 22.03 (8)° and between the isoxazole and cyclo-hexa-nol rings is 30.15 (8)°. The corresponding values in the second mol-ecule are 6.13 (10) and 88.44 (8)°, respectively. In the crystal, the molecules are linked by O-H⋯O and O-H⋯N hydrogen bonds, building up a zigzag chain parallel to the a axis.
منابع مشابه
4-[6,8-Dibromo-2-(2-chloro-5-nitrophenyl)-1,2,3,4-tetrahydroquinazolin-3-yl]cyclohexanol
The title compound, C(20)H(20)Br(2)ClN(3)O(3), was synthesized by the condensation reaction of 2-chloro-5-nitro-benzaldehyde with 4-(2-amino-3,5-dibromo-benzyl-amino)cyclo-hexa-nol in a methanol solution. There are two independent mol-ecules in the asymmetric unit and in one mol-ecule the atoms of the cyclo-hexane ring are disordered over two sets of sites with refined occupancies of 0.657 (12)...
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